Testosterone androgen receptors

androgen receptors are cellular ignition switches that are activated by androgens (testosterone, dihydrotestosterone, and other hormones) that initiate a process that leads to the production of proteins, the physical building blocks of tissues and, in particular, muscle.
androgen receptors are found in muscle and other tissues throughout the body.
When receptors from androgens in muscle are activated, they have a direct effect on the target muscle tissue, which will interact with other proteins and participate in other actions that lead to muscle growth.

The discovery of androgens “testosterone”

Androgens were first discovered in 1936.
Since then, testosterone and many other anabolic steroids have been synthesized by special chemical laboratories and marketed for exogenous use.
Forty-five would have lasted between the discovery of the first androgens and the period that followed. years old. androgen receptors in muscle.
Due to a lack of knowledge about androgen receptors in muscle, scientists have wondered how anabolic steroids work in muscle tissue for many years. Some even wondered if they worked, they believed there were enough endogenous androgens in the human body to saturate the androgen receptors. This would mean that taking anabolic steroids would have no benefit for muscle growth. It was also thought that androgen receptors would decrease after puberty, which means there would be fewer receptors for androgens and steroids to target. Another opinion was that anabolic steroids do not act outside the receptor region.
This is clearly wrong due to the indirect actions that anabolic steroids exert outside the androgen receptor, which affects muscle growth.

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It is still argued that there is a saturation point when taking anabolic steroids.

This is true to a certain extent.
As with creatine monohydrate, or any other supplement, the body has a point. saturation.
This means that there is a limit to what can be used by the body.
Each person contains a certain amount of androgen receptors.
As with any other compound, the number of receptors present varies from person to person from – due to several factors.
The presence of muscle mass, the type of muscle fibers and the level of physical activity of a person can affect the density of androgen receptors and thus alter the number of androgen receptors present in each person. In fact, there is a saturation point for testosterone or any other anabolic steroid.
This question has often been discussed.
Many people think that taking more than 1000 mg of testosterone per week is useless, and there are people who believe that saturation is even less meaningful. than 500 mg.
Obviously, the number of androgen receptors present in a person will determine where this saturation point is.
This mentality has a mentality that anabolic steroids can only work at the androgen receptor, not outside. All steroids have what is called a binding affinity.A steroid with a higher binding affinity has the ability to bind to receptors at a higher rate. This leads to the activation of more androgen receptors, and this thought helps us understand how we can increase the volume of muscle growth.
nandrolone and testosterone showed high binding affinity, however oxymetelone, methandrostenolone, and stanozolol have low binding affinity, and they are considered some of the most powerful anabolic steroids available.
All of this shows that more types of anabolic steroids are used for muscle growth than the action that occurs with the androgen receptor.

Testosterone and IGF-1

IGF-1 is one of the most anabolic hormones in the body .. Testosterone has been shown to cause a significant spike in IGF-1 levels in the body. Nandrolone has also been shown to cause a decrease in a specific protein that binds to IGF-1. This increases the active amount of IGF-1 circulating in the body. It is believed that many other anabolic steroids, especially those with a low affinity binder, cause anabolism through their effect on IGF-1.
There are many other factors that can contribute to these low binding affinity steroids that are so effective because that the action of androgens is an extremely complex chain of events.

Anabolic steroids and cortisol

Many anabolic steroids have been shown to bind to cortisol receptors.
Cortisol is a stress-releasing hormone that it is (due to physical or psychological stress, illness, or lack of night rest. br> Cortisol is not the best hormone when you are trying to increase muscle mass or the loss of body fat can actually create an environment that works the other way around.
When anabolic steroids bind to cortisol receptors, cortisol is unable to exert its effect. All of this, on the one hand, will protect the body from loss of muscle mass or the accumulation of fat that might otherwise occur (on the other hand, it makes the body as a whole more susceptible to inflammatory risks in general le).
This is an indirect way that anabolic steroids are anabolic without being bound to androgen receptors.

The importance of white fibers (type II) for increasing androgen receptors

The number of androgen receptors in the body affects the effectiveness of certain steroids. Type II muscle fibers (white fibers) have been shown to enhance androgen receptors. This indicates that strength training that increases type II fibers will determine the presence of more androgen receptors. The amount of androgen receptors present in the body affects the effectiveness of certain steroids.

Does the use of anabolic steroids decrease androgen receptors?

Take, for example, a professional bodybuilder who has been using anabolic steroids for many years.
Many athletes think that if in their first steroid cycle they took for example 10 kg of muscle mass, another should follow, they can take the same with a second cycle.
This does not really happen for the so-called “downregulation” of receptors.
Anabolic steroids will only allow someone to grow to a certain size, with a certain genetics.
Regardless of what medications are taken, genetics will restrict body growth.
When someone gains 30 pounds in their first steroid cycles, it would be unrealistic to believe that they will gain infinitely again over the next few times.
(Someone also clings that the gained muscle volume can be maintained even after stopping the use of anabolic steroids. In reality, what will be supported is only adaptation of the receptors to welcome those dosages).
Androgen receptors are often discussed , suppression and ways to prevent it.
Androgen receptors play a role in anabolism, but this is not the whole picture.
For example, Dianabol is one of the most powerful steroids, used for over fifty years, and binds to low levels of androgen receptors (suppression) .